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Increased soluble human leukocyte antigen-G levels in peripheral blood from climbers on Mount Everest.

Abstract
Soluble human leukocyte antigen-G (HLA-G) is involved in maternal-fetal tolerance, transplant acceptance, and tumor escape from immunosurveillance, operating by inhibiting activity of T, antigen presenting cells (APC), and natural killer (NK) cells. HLA-G gene expression is modulated in vitro after hypoxic conditions, a situation evidenced during pregnancy and tumor progression. In extreme altitude, mountaineers are in hypoxic conditions that generate physiologic adaptative responses, some of them giving rise to pathologic signs. We performed measurements of plasma soluble HLA-G in six climbers before departure of the expedition and during their ascent to and descent from summit of Mount Everest, and in 3 Sherpas at 5300-6400 m. We found that HLA-G levels are upregulated during the ascent with a unique pattern in comparison with angiogenic/lymphangiogenic factors. Our data suggest that HLA-G has to be taken into account in the mechanisms participating in adaptation to high altitudes and reinforce hypoxia as an important factor in the regulation of HLA-G expression.
AuthorsMichel Bourguignon, Layale Yaghi, Sébastien Flajollet, Irène Radanne-Krawice, Nathalie Rouas-Freiss, Didier Lugrin, Jean-Paul Richalet, Edgardo D Carosella, Philippe Moreau
JournalHuman immunology (Hum Immunol) Vol. 71 Issue 11 Pg. 1105-8 (Nov 2010) ISSN: 1879-1166 [Electronic] United States
PMID20732367 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Biomarkers
  • HLA Antigens
  • HLA-G Antigens
  • Histocompatibility Antigens Class I
  • Oxygen
Topics
  • Adult
  • Altitude
  • Biomarkers (blood)
  • Environmental Exposure (adverse effects)
  • Enzyme-Linked Immunosorbent Assay
  • Gene Expression Regulation
  • HLA Antigens (biosynthesis, blood, genetics)
  • HLA-G Antigens
  • Histocompatibility Antigens Class I (biosynthesis, blood, genetics)
  • Humans
  • Hypoxia (blood, diagnosis, etiology, physiopathology)
  • Mountaineering (physiology)
  • Oxygen (metabolism)
  • Stress, Physiological (immunology)

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