Abstract | BACKGROUND: Immunosuppression is a known risk factor for anal human papillomavirus (HPV) disease, including anal squamous cell carcinoma. Additional risk factors for HPV-related disease have not been studied in the renal transplant population. The demographics of anal HPV and associated risk factors were investigated in this population. METHODS: Anal cytology and polymerase chain reaction were used to assess anal HPV disease in a cohort of transplant recipients at the Royal London Hospital. Risk factors associated with increased immunosuppression and HPV exposure were collated to determine any association with anal disease. RESULTS: Anal dysplasia was associated with anal oncogenic HPV infection (P < 0.001), duration of immunosuppression (P = 0.050), previous genital warts (P = 0.018) and receptive anal intercourse (P = 0.013). CONCLUSION: Anal dysplasia was related to immunosuppression and patient factors in this cohort.
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Authors | H S Patel, A R Silver, T Levine, G Williams, J M Northover |
Journal | The British journal of surgery
(Br J Surg)
Vol. 97
Issue 11
Pg. 1716-21
(Nov 2010)
ISSN: 1365-2168 [Electronic] England |
PMID | 20730855
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. |
Chemical References |
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Topics |
- Anal Canal
(pathology)
- Anus Neoplasms
(etiology)
- Carcinoma, Squamous Cell
(etiology)
- DNA
(analysis)
- Epidemiologic Methods
- Female
- Humans
- Immunosuppression Therapy
(adverse effects)
- Kidney Transplantation
- Male
- Middle Aged
- Papillomavirus Infections
(complications)
- Polymerase Chain Reaction
- Sexual Behavior
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