Although there have been many studies investigating a possible association between p53
codon 72 polymorphism and risk of
bladder cancer, the results have been inconsistent. We conducted a meta-analysis of six epidemiological studies, which included 597
bladder cancer cases and 731 controls. Patients with
bladder cancer had a significantly lower frequency of
Pro/Arg [odds ratio (OR) = 0.80, 95% confidence interval (CI) = 0.64-0.99], when compared to controls. Stratifying for race, we found that among Caucasians, patients with
bladder cancer had a significantly higher frequency of
Arg/Arg (OR = 1.64, 95%CI = 1.18-2.28) and a lower frequency of
Pro/Arg (OR = 0.62, 95%CI = 0.44-0.86), compared to controls. Stratifying various studies by the stage of
bladder cancer, we found that invasive
bladder cancers had a significantly lower frequency of
Arg/Arg (OR = 0.58, 95%CI = 0.36-0.93) and a higher frequency of
Pro/Arg (OR = 0.62, 95%CI = 0.44-0.86) than did non-invasive
bladder cancers. No significant association was found between this genotype and human papilloma virus. Based on our meta-analysis, we suggest that p53
codon 72 polymorphism is associated with
bladder cancer and that genotypic distribution of this polymorphism varies with the stage of
bladder cancer.