Meta-analysis of epidemiological studies of association of P53 codon 72 polymorphism with bladder cancer.

Although there have been many studies investigating a possible association between p53 codon 72 polymorphism and risk of bladder cancer, the results have been inconsistent. We conducted a meta-analysis of six epidemiological studies, which included 597 bladder cancer cases and 731 controls. Patients with bladder cancer had a significantly lower frequency of Pro/Arg [odds ratio (OR) = 0.80, 95% confidence interval (CI) = 0.64-0.99], when compared to controls. Stratifying for race, we found that among Caucasians, patients with bladder cancer had a significantly higher frequency of Arg/Arg (OR = 1.64, 95%CI = 1.18-2.28) and a lower frequency of Pro/Arg (OR = 0.62, 95%CI = 0.44-0.86), compared to controls. Stratifying various studies by the stage of bladder cancer, we found that invasive bladder cancers had a significantly lower frequency of Arg/Arg (OR = 0.58, 95%CI = 0.36-0.93) and a higher frequency of Pro/Arg (OR = 0.62, 95%CI = 0.44-0.86) than did non-invasive bladder cancers. No significant association was found between this genotype and human papilloma virus. Based on our meta-analysis, we suggest that p53 codon 72 polymorphism is associated with bladder cancer and that genotypic distribution of this polymorphism varies with the stage of bladder cancer.
AuthorsD B Li, X Wei, L H Jiang, Y Wang, F Xu
JournalGenetics and molecular research : GMR (Genet Mol Res) Vol. 9 Issue 3 Pg. 1599-605 ( 2010) ISSN: 1676-5680 [Electronic] Brazil
PMID20730711 (Publication Type: Journal Article, Meta-Analysis)
Chemical References
  • Codon
  • Tumor Suppressor Protein p53
  • Codon (genetics)
  • Humans
  • Polymorphism, Genetic (genetics)
  • Tumor Suppressor Protein p53 (genetics)
  • Urinary Bladder Neoplasms (epidemiology, genetics)

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