Abstract |
Patent foramen ovale (PFO), a relatively common abnormality in adults, has been associated with migraine. Few studies also linked PFO with cluster headache (CH). To verify whether right-to-left shunt (RLS) is related to headaches other than migraine and CH, we used transcranial Doppler following microbubbles injection to detect shunts in 24 CH, 7 paroxysmal hemicrania (PH), one SUNCT, two hemicrania continua (HC) patients; and 34 matched controls. RLS was significantly more frequent in CH than in controls (54% vs. 25%, p=0.03), particularly above the age of 50. In the HC+PH+SUNCT group, RLS was found in 6 patients and in 2 controls (p=0.08). Smoking as well as the Epworth Sleepiness Scale correlated significantly with CH, smoking being more frequent in patients with RLS. PFO may be non-specifically related to trigeminal autonomic cephalalgias and HC. The headache phenotype in PFO patients probably depends on individual susceptibility to circulating trigger factors.
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Authors | Vanise Amaral, Gabriel R de Freitas, Bruno C B Rodrigues, Daniel de H Christoph, Carlos A de Pinho, Cristiana de Faria P Góes, Maurice B Vincent |
Journal | Arquivos de neuro-psiquiatria
(Arq Neuropsiquiatr)
Vol. 68
Issue 4
Pg. 627-31
(Aug 2010)
ISSN: 1678-4227 [Electronic] Germany |
PMID | 20730322
(Publication Type: Journal Article)
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Topics |
- Adult
- Case-Control Studies
- Female
- Foramen Ovale, Patent
(complications, diagnostic imaging, physiopathology)
- Headache
(diagnostic imaging, etiology, physiopathology)
- Humans
- Male
- Middle Aged
- Trigeminal Autonomic Cephalalgias
(diagnostic imaging, etiology, physiopathology)
- Ultrasonography, Doppler, Transcranial
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