In the present study we investigated the effects of
lipoic acid (LA) on
acetylcholinesterase (AChE),
glutathione peroxidase (GPx) and Na+, K+-
ATPase activities in rat hippocampus during
seizures. Wistar rats were treated with
0.9% saline (i.p., control group),
lipoic acid (20 mg/kg, i.p., LA group),
pilocarpine (400 mg/kg, i.p., P400 group), and the association of
pilocarpine (400 mg/kg, i.p.) plus LA (20 mg/kg, i.
p.), 30 min before of administration of P400 (
LA plus P400 group). After the treatments all groups were observed for 1 h. In P400 group, there was a significant increase in GPx activity as well as a decrease in AChE and Na+, K+-
ATPase activities after
seizures. In turn,
LA plus P400 abolished the appearance of
seizures and reversed the decreased in AChE and Na+, K+-
ATPase activities produced by
seizures, when compared to the P400 seizing group. The results from the present study demonstrate that preadministration of LA abolished seizure episodes induced by
pilocarpine in rat, probably by increasing AChE and Na+, K+-
ATPase activities in rat hippocampus.