Uncovering the roles of PINK1 and parkin in mitophagy.

Abstract

Parkinson disease (PD) is the second most prevalent neurodegenerative disorder, and thus elucidation of the pathogenic mechanism and establishment of a fundamental cure is essential in terms of public welfare. Fortunately, our understanding of the pathogenesis of two types of recessive familial PDs--early-onset familial PD caused by dysfunction of the PTEN induced putative kinase 1 (PINK1) gene and autosomal recessive juvenile Parkinsonism (ARJP) caused by a mutation in the Parkin gene--has evolved and continues to expand.

• Authors: Noriyuki Matsuda, Keiji Tanaka
• Journal: Autophagy (Autophagy) Vol. 6 Issue 7 Pg. 952-4 (Oct 2010) ISSN: 1554-8635 [Electronic] United States
• PMID: 20724841 (Publication Type: Journal Article)

Chemical References

• Ubiquitin-Protein Ligases
• parkin protein
• Protein Kinases
• PTEN-induced putative kinase

Topics

• Autophagy (physiology)
• Humans
• Mitochondria (pathology)
• Mutation
• Parkinson Disease (genetics, pathology, physiopathology)
• Parkinsonian Disorders (genetics, pathology, physiopathology)
• Protein Kinases (genetics, metabolism)
• Ubiquitin-Protein Ligases (genetics, metabolism)