Lgl, the SWH pathway and tumorigenesis: It's a matter of context & competition!

Abstract	Loss of function of the neoplastic tumors suppressors, lgl, scrib and dlg or overexpression of the apical polarity components, Crumbs and atypical protein kinase C (aPKC), are associated with polarity loss and tissue overgrowth, however, the mechanism behind these effects is poorly understood. In our recent study, we showed that Lgl, aPKC and Crumbs mediate their effects on proliferation and survival via the Salvador/Warts/Hippo (SWH) tumor suppressor pathway. Loss of lgl can lead to substantial overgrowth, however the lgl mutant phenotype can be quite variable and the amount of overgrowth of the mutant tissue, its survival and ultimate fate is strongly determined by context and competition. In this extra-view we present a more detailed description of the lgl mutant phenotype and highlight the phenotypic differences between lgl and SWH pathway mutant phenotypes. In addition, we explore the role for the Jun kinase (JNK) pathway in the development of the lgl mutant phenotype.
Authors	Nicola A Grzeschik, Linda M Parsons, Helena E Richardson
Journal	Cell cycle (Georgetown, Tex.) (Cell Cycle) Vol. 9 Issue 16 Pg. 3202-12 (Aug 15 2010) ISSN: 1551-4005 [Electronic] United States
PMID	20724829 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Cell Cycle Proteins Drosophila Proteins Intracellular Signaling Peptides and Proteins Membrane Proteins Scrib protein, Drosophila Tumor Suppressor Proteins crb protein, Drosophila l(2)gl protein, Drosophila sav protein, Drosophila dlg1 protein, Drosophila Protein Kinases wts protein, Drosophila Protein Serine-Threonine Kinases hpo protein, Drosophila MAP Kinase Kinase 4
Topics	Animals Apoptosis Cell Cycle Proteins (metabolism) Drosophila (metabolism) Drosophila Proteins (genetics, metabolism, physiology) Intracellular Signaling Peptides and Proteins (metabolism) MAP Kinase Kinase 4 (metabolism) Membrane Proteins (metabolism) Mutation Neoplasms (etiology) Protein Kinases (metabolism) Protein Serine-Threonine Kinases (metabolism) Signal Transduction Tumor Suppressor Proteins (genetics, metabolism, physiology)

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