[Pituitary adenoma with alpha, 17-39 ACTH and beta, MSH cells, without hypercorticism (author's transl)].

Abstract

In one case of pituitary basophil adenoma, the majority of the cells contains numerous small granulations which, by using immunohistoenzymatic technique, react with alpha, 17-39 ACTH and beta, MSH antisera. The reaction with anti beta, 1-24 ACTH is negative. The radioimmunoassay of ACTH reveals an increase of plasmatic ACTH, but the cortisol cycle stays low. This data suggests that this functional adenoma releases a product of which has an immunological relationship with ACTH, without biological activity.

• Authors: G Tramu, J C Beauvillain, M Mazzuca, M Linquette, J Lefebvre, P Fossati, J L Christiaens
• Journal: Annales d'endocrinologie (Ann Endocrinol (Paris)) Vol. 39 Issue 1 Pg. 51-2 ( 1978) ISSN: 0003-4266 [Print] France
• Vernacular Title: Adénome hypophysaire à cellules à alpha, 17-39 ACTH et beta, MSH sans hypercorticisme.
• PMID: 207217 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Adrenocorticotropic Hormone
• Melanocyte-Stimulating Hormones
• Hydrocortisone

Topics

• Adenoma, Basophil (analysis)
• Adrenocorticotropic Hormone (analysis, blood)
• Aged
• Cytoplasmic Granules (analysis)
• Histocytochemistry
• Humans
• Hydrocortisone (blood)
• Male
• Melanocyte-Stimulating Hormones (analysis)
• Pituitary Neoplasms (analysis)