Abstract | BACKGROUND: METHODS:
Diloxanide furoate was administered to improve intractable intestinal amoebiasis after a recurring amoebic infection that tends to occur via coprophagy in mentally disabled individuals infected with E. histolytica at an institution (the prevalence rate and positive serology rate were 38.2 and 67.1%, respectively). The therapeutic effect of the drugs was judged by microscopic stool examination and an E. histolytica antigen detection kit. RESULTS: CONCLUSIONS: Combination therapy successfully cured and prevented transmission of the mass E. histolytica infection at the institution.
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Authors | Tsukasa Fujishima, Shoichi Nishise, Masahiro Ichihara, Seiki Kobayashi, Tsutomu Takeuchi |
Journal | Chemotherapy
(Chemotherapy)
Vol. 56
Issue 4
Pg. 348-52
( 2010)
ISSN: 1421-9794 [Electronic] Switzerland |
PMID | 20720419
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 S. Karger AG, Basel. |
Chemical References |
- Amebicides
- Furans
- Metronidazole
- diloxanide furoate
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Topics |
- Amebicides
(therapeutic use)
- Drug Resistance
- Drug Therapy, Combination
- Dysentery, Amebic
(drug therapy, epidemiology, parasitology)
- Entamoeba histolytica
(drug effects, genetics, immunology)
- Enzyme-Linked Immunosorbent Assay
- Feces
(parasitology)
- Female
- Furans
(therapeutic use)
- Humans
- Japan
(epidemiology)
- Male
- Metronidazole
(therapeutic use)
- Persons with Mental Disabilities
- Rehabilitation Centers
- Treatment Outcome
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