Abstract |
Our retrospective study for ultrasonic nebulised pentamidine in 13 patients shows that 7 of 8 patients with Pneumocystis carinii pneumonia (PCP), proven by biopsy examination, were cured (recovery rate, 88%). Two of these 8 patients were mainly treated by nebulised pentamidine and the other 5 patients were administered parenteral pentamidine before the nebulised pentamidine therapy and the final 1 patient died on day 9 without clinical improvement with nebulised pentamidine as well as conventional therapy ( trimethoprim- sulphamethoxazole, parenteral pentamidine). No relapse occurred in the 7 cured patients. The inhalation increased the cough in 4 of 13 cases and caused vomiting in 1 patient. Two patients discontinued the nebulisation because of the side-effect. No extra-pulmonary side-effects of nebulised pentamidine were seen. These results show that an efficacy of nebulised pentamidine is at least equal to conventional therapy with fewer side-effects and that only patients with mild PCP without severe hypoxaemia are eligible for the inhalation therapy.
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Authors | K Tanabe, H Goto, K Shimada |
Journal | Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
(Kansenshogaku Zasshi)
Vol. 65
Issue 3
Pg. 299-303
(Mar 1991)
ISSN: 0387-5911 [Print] Japan |
PMID | 2071948
(Publication Type: Clinical Trial, English Abstract, Journal Article)
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Chemical References |
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Topics |
- Aerosols
- Female
- Humans
- Male
- Pentamidine
(administration & dosage, therapeutic use)
- Pneumonia, Pneumocystis
(drug therapy)
- Retrospective Studies
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