Abstract | OBJECTIVES/HYPOTHESIS: STUDY DESIGN: METHODS: Adult rats were randomly assigned to two experimental treatment groups: a group treated with systemic steroid (n = 13) and a control group treated with saline (n = 13). Treatment was initiated 21 hours after infection and repeated once a day for three days. Hearing loss and cochlear damage were assessed by distortion product otoacoustic emissions (DPOAE), auditory brainstem response (ABR) at 16 kHz, and spiral ganglion neuron density. RESULTS: Fifty-six days after infection, steroid treatment significantly reduced hearing loss assessed by DPOAE (P < .05; Mann-Whitney) and showed a trend toward reducing loss of viable neurons in the spiral ganglion (P = .0513; Mann-Whitney). After pooling data from day 22 with data from day 56, we found that systemic steroid treatment significantly reduced loss of spiral ganglion neurons (P = .0098; Mann-Whitney test). CONCLUSIONS:
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Authors | Lise Worsøe, Christian Thomas Brandt, Søren Peter Lund, Christian Østergaard, Jens Thomsen, Per Cayé-Thomasen |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 120
Issue 9
Pg. 1872-9
(Sep 2010)
ISSN: 1531-4995 [Electronic] United States |
PMID | 20717948
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Betamethasone
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Betamethasone
(pharmacology)
- Cochlea
(drug effects, pathology)
- Evoked Potentials, Auditory, Brain Stem
(drug effects)
- Hearing Loss, Sensorineural
(drug therapy, pathology)
- Injections, Intramuscular
- Male
- Meningitis, Pneumococcal
(drug therapy, pathology)
- Neurons
(drug effects, pathology)
- Otoacoustic Emissions, Spontaneous
(drug effects)
- Rats
- Rats, Wistar
- Spiral Ganglion
(drug effects, pathology)
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