Abstract | BACKGROUND:
TSG101 protein is one of the key factors in Endosomal sorting pathway. The abnormality of this pathway could decrease degradation of Notch receptor which leads to disorder of cell differentiation and development in drosophila. In mammal, the Notch3 receptors correlate with lung tissue development and lung carcinogenesis. The purpose of this study is to explore the relationship between TSG101 protein and Notch3 receptor in human lung cancer. METHODS: Immunohistochemical method (S-P method) and Western blot were applied to detect the expressions of TSG101 protein and Notch3 receptor in lung cancer tissues and cell lines, in comparison with the corresponding normal tissues and cell lines. Besides, the expression of Notch3 receptor was observed when TSG101 protein was blocked by its specific antibody. RESULTS: CONCLUSIONS:
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Authors | Jiahui Chang, Ping Lu, Cunwei Cai, Fei Li, Zhiyong Zhong, Daorong Zhang |
Journal | Zhongguo fei ai za zhi = Chinese journal of lung cancer
(Zhongguo Fei Ai Za Zhi)
Vol. 12
Issue 2
Pg. 111-6
(Feb 20 2009)
ISSN: 1999-6187 [Electronic] China |
PMID | 20716402
(Publication Type: English Abstract, Journal Article)
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