Abstract |
Chronic inflammation contributes to a substantial part of environmental carcinogenesis. Various infectious diseases and physical, chemical, and immunological factors participate in inflammation-related carcinogenesis. Under inflammatory conditions, reactive oxygen and nitrogen species are generated from inflammatory and epithelial cells, and resulting DNA damage may participate in carcinogenesis. 8-Nitroguanine is a mutagenic DNA lesion formed during chronic inflammation. We performed immunohistochemical analysis, and demonstrated that 8-nitroguanine was formed at the sites of carcinogenesis in animal models and patients with various cancer-prone infectious and inflammatory diseases, caused by parasites, viruses, and asbestos exposure. In asbestos-exposed mice, 8-nitroguanine was formed in bronchial epithelial cells, and it is noteworthy that crocidolite induced significantly more intense 8-nitroguanine formation than chrysotile, inconsistent with their carcinogenic potentials. On the basis of these findings, we have proposed that 8-nitroguanine could be a potential biomarker to evaluate the risk of inflammation-related carcinogenesis.
|
Authors | Yusuke Hiraku, Shosuke Kawanishi, Takamichi Ichinose, Mariko Murata |
Journal | Annals of the New York Academy of Sciences
(Ann N Y Acad Sci)
Vol. 1203
Pg. 15-22
(Aug 2010)
ISSN: 1749-6632 [Electronic] United States |
PMID | 20716278
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
|
Chemical References |
- 8-nitroguanine
- Biomarkers, Tumor
- Inflammation Mediators
- Asbestos
- Guanine
- NOS2 protein, human
- Nitric Oxide Synthase Type II
|
Topics |
- Animals
- Asbestos
(adverse effects, toxicity)
- Bacterial Infections
(enzymology, microbiology, pathology)
- Biomarkers, Tumor
(adverse effects, physiology, toxicity)
- Cell Transformation, Neoplastic
(chemically induced, genetics, pathology)
- DNA Damage
(physiology)
- Guanine
(adverse effects, analogs & derivatives, physiology)
- Humans
- Inflammation Mediators
(physiology)
- Nitric Oxide Synthase Type II
(physiology)
- Parasitic Diseases
(enzymology, parasitology, pathology)
- Virus Diseases
(enzymology, pathology, virology)
|