Evelynin, a cytotoxic benzoquinone-type Retro-dihydrochalcone from Tacca chantrieri.

Abstract

A new benzoquinone-type retro-dihydrochalcone, named evelynin, was isolated from the roots and rhizomes of Tacca chantrieri. The structure was elucidated on the basis of the analysis of spectroscopic data and confirmed by a simple one-step total synthesis. Evelynin exhibited cytotoxicity against four human cancer cell lines, MDA-MB-435 melanoma, MDA-MB-231 breast, PC-3 prostate, and HeLa cervical carcinoma cells, with IC(50) values of 4.1, 3.9, 4.7, and 6.3 μM, respectively.

• Authors: Jiangnan Peng, Evelyn M Jackson, David J Babinski, April L Risinger, Gregory Helms, Doug E Frantz, Susan L Mooberry
• Journal: Journal of natural products (J Nat Prod) Vol. 73 Issue 9 Pg. 1590-2 (Sep 24 2010) ISSN: 1520-6025 [Electronic] United States
• PMID: 20715765 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antineoplastic Agents, Phytogenic
• Benzoquinones
• Chalcones
• evelynin
• dihydrochalcone

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Benzoquinones (chemistry, isolation & purification, pharmacology)
• Chalcones (chemistry, isolation & purification, pharmacology)
• Dioscoreaceae (chemistry)
• Drug Screening Assays, Antitumor
• Female
• HeLa Cells
• Humans
• Inhibitory Concentration 50
• Male
• Rhizome (chemistry)