Thyroid function and 3,3'-diiodothyronine sulfate cross-reactive substance (compound W) in maternal hyperthyroidism with antithyroid treatment.

Abstract

OBJECTIVE:

To test whether the serial measurement of maternal levels of compound W, a 3,3'-diiodothyronine sulfate cross-reactive substance, can serve as a potential indicator of fetal thyroid function in pregnant women receiving antithyroid medication.

METHODS:

Compound W was measured repeatedly in serum of pregnant women with hyperthyroidism treated with antithyroid medication. Free thyroxine levels of mothers and serum thyroid-stimulating hormone levels of 1-day-old neonates were analyzed by local clinical or state laboratories.

RESULTS:

Use of minimal antithyroid medication impaired the progressive increase of compound W seen in euthyroid mothers during pregnancy. At term, depressed compound W levels in maternal serum were found in 7 of 22 pregnancies; in 1 case, maternal compound W was suppressed and newborn thyroid-stimulating hormone was elevated. Seven mothers with treated hyperthyroidism failed to show an increase in serum levels of compound W after midterm.

CONCLUSION:

Normal progression of maternal serum compound W may be an index of normal fetal thyroid development in mothers with hyperthyroidism treated with necessary antithyroid medication.

• Authors: Lester Vanmiddlesworth, N Rue Vanmiddlesworth, Robert S Egerman, Andrew J Bush, Risa D Ramsey, Lucinda P Delmar, Eugene C Ho, Sing-Yung Wu
• Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists (Endocr Pract) 2011 Mar-Apr Vol. 17 Issue 2 Pg. 170-6 ISSN: 1934-2403 [Electronic] United States
• PMID: 20713348 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antithyroid Agents
• Diiodothyronines
• compound W
• Thyroxine

Topics

• Adolescent
• Adult
• Antithyroid Agents (adverse effects, therapeutic use)
• Diiodothyronines (blood)
• Female
• Humans
• Hyperthyroidism (blood, drug therapy)
• Infant, Newborn
• Pregnancy
• Thyroid Gland (embryology)
• Thyroxine (blood)
• Young Adult