Anti-metastatic activity in vivo of MDP-L-alanyl-cholesterol (MTP-Chol) entrapped in nanocapsules.

Abstract

A lipophilic muramylpeptide (MTP-Chol), capable of rendering macrophages cytostatic towards tumour cells, was encapsulated within polyisobutylcyanoacrylate nanocapsules and administered to mice carrying an experimental model of liver metastasis. Treatment by intravenous injections twice a week beginning before the establishment of metastases significantly reduced the number of liver colonies. Treatment started later was less effective. The dose of MTP-Chol in each injection, and the tumour burden in the mice did not change the percentage inhibition of metastases significantly. Anti-metastatic activity was also observed after administering nanocapsules containing MTP-Chol by the oral route.

• Authors: W P Yu, G M Barratt, J P Devissaguet, F Puisieux
• Journal: International journal of immunopharmacology (Int J Immunopharmacol) Vol. 13 Issue 2-3 Pg. 167-73 ( 1991) ISSN: 0192-0561 [Print] England
• PMID: 2071294 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Capsules
• Cholesterol Esters
• Acetylmuramyl-Alanyl-Isoglutamine
• N-acetylmuramyl-alanyl-isoglutamine-alanyl-cholesterol

Topics

• Acetylmuramyl-Alanyl-Isoglutamine (administration & dosage, analogs & derivatives)
• Animals
• Antineoplastic Agents (administration & dosage)
• Capsules
• Cholesterol Esters (administration & dosage)
• Dose-Response Relationship, Drug
• Female
• Macrophage Activation (drug effects)
• Mice
• Mice, Inbred C57BL
• Neoplasms, Experimental (drug therapy, immunology, secondary)