Spinal epidural lipomatosis due to a bronchial ACTH-secreting carcinoid tumour.

Abstract

Spinal epidural lipomatosis (SEL) is a rare condition characterized by abnormal deposits of fat in the epidural space. In a severe form this may cause compression of neural elements. This is the second report of SEL secondary to a carcinoid tumour. Our patient was a 34-year-old Caucasian male farm worker presenting with acute spinal cord compression. He had gained 11kg, and had developed Type II diabetes mellitus in the preceding 12months. On examination he displayed characteristic features of Cushing's syndrome. MRI demonstrated posterior epidural lipomatosis, with cord compression from T3 to T8. Urgent spinal cord decompression was performed. Further investigation confirmed a biochemical Cushing's syndrome secondary to an ACTH-producing pulmonary carcinoid tumour.

• Authors: K Bhatia, E Frydenberg, T Steel, M Ow-Yang, K Ho, E Grainger
• Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci) Vol. 17 Issue 11 Pg. 1461-2 (Nov 2010) ISSN: 1532-2653 [Electronic] Scotland
• PMID: 20709555 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Adrenocorticotropic Hormone

Topics

• Adrenocorticotropic Hormone (blood, metabolism)
• Adult
• Carcinoid Tumor (complications, metabolism, pathology)
• Cushing Syndrome (etiology, physiopathology)
• Humans
• Lipomatosis (etiology, pathology, physiopathology)
• Lung Neoplasms (complications, metabolism, pathology)
• Male
• Spinal Cord Compression (etiology, pathology, physiopathology)
• Treatment Outcome