[Protective activity of different concentration of tea polyphenols and its major compound EGCG against whole body irradiation-induced injury in mice].

Abstract

OBJECTIVE:

To evaluate the different concentrate of tea polyphenols (TP) and its compound for irradiation-protection and investigate its mechanism.

METHOD:

To evaluate the radioprotective activity, mice were exposed to whole body gamma irradiation. TP 80 and TP 50 (50, 10 mg x kg(-1)) and its major constituent epigallocatechin gallate (EGCG) (50, 10 mg x kg(-1)) were administered after irradiation to examine its inhibition against irradiation-induced injury.

RESULT:

This study indicate that in comparison with non-irradiated controls, irradiation resulted in a significant reduction the spleen index (spleen weight/body weight 100), haematological parameters (RBC, WBC and PLT), activity of superoxide dismutase (SOD), and increase of malondialdehde (MDA) level in 28 days. Oral administration of TP (50 mg x kg(-1)) shown the best effect on reducing the irradiation-induced injury on mice studied, and showed a protective effect against irradiation-induced haematological parameters (RBC, WBC and PLT), the spleen index and MDA level significant reduction, and antioxidase activity (SOD) decrease.

CONCLUSION:

The results suggest that TP 50 mg x kg(-1) and EGCG have in vivo antioxidant potential and radioprotective activity against whole body gamma irradiation in mice. It may be concluded that TP (50% EGCG) possess good irradiation-protective and antioxidant effect.

• Authors: Shaolai Guo, Yuan Hu, Ping Liu, Yuyu Wang, Daihong Guo, Dongxiao Wang, Hongho Liao
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 35 Issue 10 Pg. 1328-31 (May 2010) ISSN: 1001-5302 [Print] China
• PMID: 20707208 (Publication Type: English Abstract, Journal Article)

Chemical References

• Flavonoids
• Phenols
• Plant Extracts
• Polyphenols
• Radiation-Protective Agents
• Catechin
• epigallocatechin gallate
• Superoxide Dismutase

Topics

• Animals
• Camellia sinensis (chemistry)
• Catechin (administration & dosage, analogs & derivatives)
• Disease Models, Animal
• Female
• Flavonoids (administration & dosage)
• Humans
• Male
• Mice
• Phenols (administration & dosage)
• Plant Extracts (administration & dosage)
• Polyphenols
• Radiation Injuries (drug therapy, enzymology, prevention & control)
• Radiation-Protective Agents (administration & dosage)
• Random Allocation
• Superoxide Dismutase (blood)
• Whole-Body Irradiation (adverse effects)