Abstract | CONTEXT:
Cyanide is a rapidly acting cellular poison, primarily targeting cytochrome c oxidase, and is a common occupational and residential toxin, mostly via smoke inhalation. Cyanide is also a potential weapon of mass destruction, with recent credible threats of attacks focusing the need for better treatments, as current cyanide antidotes are limited and impractical for rapid deployment in mass casualty settings. OBJECTIVE: MATERIALS AND METHODS: We studied Cbi in both an inhaled and intraperitoneal model of cyanide poisoning in mice. RESULTS: DISCUSSION AND CONCLUSION: These studies demonstrate that Cbi is a highly effective cyanide antidote in mouse models, and suggest it could be used in a mass casualty setting, because it can be given rapidly as an intramuscular injection when administered as Cbi-SO(3). Based on these animal data Cbi-SO(3) appears to be an antidote worthy of further testing as a therapy for mass casualties.
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Authors | Adriano Chan, Maheswari Balasubramanian, William Blackledge, Othman M Mohammad, Luis Alvarez, Gerry R Boss, Timothy D Bigby |
Journal | Clinical toxicology (Philadelphia, Pa.)
(Clin Toxicol (Phila))
Vol. 48
Issue 7
Pg. 709-17
(Aug 2010)
ISSN: 1556-9519 [Electronic] England |
PMID | 20704457
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Antidotes
- Cobamides
- Cyanides
- cobinamide
- Hydroxocobalamin
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Topics |
- Administration, Inhalation
- Animals
- Antidotes
(therapeutic use)
- Cobamides
(administration & dosage, therapeutic use)
- Cyanides
(pharmacokinetics, poisoning)
- Dose-Response Relationship, Drug
- Hydroxocobalamin
(therapeutic use)
- Injections, Intramuscular
- Lethal Dose 50
- Male
- Mice
- Mice, Inbred C57BL
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