Efficacy and tolerability of injectable sodium valproate in patients with mania.

Abstract

BACKGROUND:

Sodium valproate is among the newer mood stabilizers and is also an anticonvulsant.

AIM:

To assess the effect of intravenous sodium valproate in patients with acute manic episodes of bipolar disorder.

METHODS:

A 1-week open trial was conducted in the year 2004-2005 at the emergency ward of the Psychiatric Centre, SMS Medical College, Jaipur, in which 30 patients participated.

CONCLUSION:

Substantial improvement was seen. No major side-effects were noted except marginal elevation of the SGOT and SGPT. The findings suggest that injectable sodium valproate is a safe and effective mood stabilizer for patients with mania.

• Authors: R K Solanki, Paramjeet Singh, Renu Khandelwal, Aarti Midha
• Journal: Indian journal of psychiatry (Indian J Psychiatry) Vol. 48 Issue 2 Pg. 118-20 (Apr 2006) ISSN: 1998-3794 [Electronic] India
• PMID: 20703399 (Publication Type: Journal Article)