The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor.
Abstract |
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Authors | Michael Hudecek, Thomas M Schmitt, Sivasubramanian Baskar, Maria Teresa Lupo-Stanghellini, Tetsuya Nishida, Tori N Yamamoto, Marie Bleakley, Cameron J Turtle, Wen-Chung Chang, Harvey A Greisman, Brent Wood, David G Maloney, Michael C Jensen, Christoph Rader, Stanley R Riddell |
Journal | Blood
(Blood)
Vol. 116
Issue 22
Pg. 4532-41
(Nov 25 2010)
ISSN: 1528-0020 [Electronic] United States |
PMID | 20702778
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Antigen, T-Cell
- ROR1 protein, human
- Receptor Tyrosine Kinase-like Orphan Receptors
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Topics |
- Adult
- B-Lymphocytes
(immunology, metabolism, pathology)
- Bone Marrow
(immunology, metabolism)
- CD8-Positive T-Lymphocytes
(immunology, metabolism)
- Cell Line, Tumor
- Gene Expression Regulation
- Gene Expression Regulation, Neoplastic
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
(genetics, immunology)
- Lymphoma, Mantle-Cell
(genetics, immunology)
- Receptor Tyrosine Kinase-like Orphan Receptors
(genetics, immunology)
- Receptors, Antigen, T-Cell
(genetics, immunology)
- T-Lymphocytes
(immunology, metabolism)
- Transduction, Genetic
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