Anti-SOX1 antibodies in patients with paraneoplastic and non-paraneoplastic neuropathy.

Abstract

Anti-SOX1 antibodies have been described to be positive in patients with paraneoplastic Lambert-Eaton myasthenic syndrome and, in a lower amount, in patients with anti-Hu positive paraneoplastic neurological syndromes, and with SCLC alone, respectively. We found 5/32 patients with paraneoplastic neuropathy and, surprisingly, 4/22 patients with neuropathy of unknown origin positive for anti-SOX1 antibodies, whereas no patient with inflammatory neuropathy and no healthy controls showed any reactivity (p=0.007). All patients with neuropathy of unknown origin where followed up for four years without diagnosis of a tumour so far. Anti-SOX1 antibodies are associated with paraneoplastic neuropathies and may define another group of non-paraneoplastic, immune-mediated neuropathies.

• Authors: M Tschernatsch, P Singh, O Gross, T Gerriets, N Kneifel, C Probst, S Malas, M Kaps, F Blaes
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 226 Issue 1-2 Pg. 177-80 (Sep 14 2010) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 20701982 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 Elsevier B.V. All rights reserved.

Chemical References

• Autoantibodies
• ELAV Proteins
• SOXB1 Transcription Factors

Topics

• Aged
• Aged, 80 and over
• Animals
• Autoantibodies (metabolism)
• Cell Line, Transformed
• ELAV Proteins (immunology)
• Female
• Humans
• Lambert-Eaton Myasthenic Syndrome (immunology, metabolism)
• Male
• Mice
• Middle Aged
• Paraneoplastic Polyneuropathy (immunology, metabolism)
• Paraneoplastic Syndromes, Nervous System (classification, immunology, metabolism)
• SOXB1 Transcription Factors (immunology)
• Transfection (methods)