Abstract | PURPOSE: METHODS: RESULTS: It was found that cells isolated from malignant ascites were more aggressive in terms of tumor growth and more resistant to chemotherapy when compared with those isolated from primary tumors. PPDC containing two copies of drugs and peptides was most efficient in treatment of primary tumors and intraperitoneal metastases. Multiple treatments with this PPDC led to almost complete regression of primary tumor and prevented growth of malignant ascites. CONCLUSION: The proposed multifunctional polymeric delivery system which consists of multiple copies of the drug and peptides demonstrated significantly higher antitumor activity in primary and metastatic cancers when compared with drug alone and PEG- CPT conjugate.
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Authors | Pooja Chandna, Jayant J Khandare, Elizabeth Ber, Lorna Rodriguez-Rodriguez, Tamara Minko |
Journal | Pharmaceutical research
(Pharm Res)
Vol. 27
Issue 11
Pg. 2296-306
(Nov 2010)
ISSN: 1573-904X [Electronic] United States |
PMID | 20700631
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Antineoplastic Agents
- DNA Primers
- Drug Carriers
- Peptides
- Polymers
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, adverse effects)
- Apoptosis
- Base Sequence
- DNA Primers
- Drug Carriers
- Female
- Humans
- Mice
- Mice, Nude
- Neoplasm Metastasis
- Neoplasms
(drug therapy, pathology)
- Peptides
(administration & dosage)
- Polymers
(administration & dosage)
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction
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