An electrophysiological study of acute tetrodotoxin poisoning.

Abstract

To evaluate the electrophysiological changes in patients with acute tetrodotoxin (TTX) poisoning from ingestion of globefish (Tetraodontidae) patients exposed to TTX were compared with age-matched controls. The cohort of TTX-poisoning cases was clinically subdivided into mild, moderate, or severe cases. The motor nerve conduction velocity (MCV), sensory nerve conduction velocity (SCV), F-wave, H-reflex, and somatosensory-evoked potentials (SEP) of the median, ulnar, and common peroneal nerve (CPN) were determined using established techniques. Four of the 64 (6.3%) TTX-poisoning cases died and were omitted from the final analysis. The MCV and SCV of the median, ulnar, and CPN nerves in all the TTX-poisoning cases were significantly slower than the healthy controls. Severe cases of TTX poisoning had more significant reduction in nerve function. Thus, electroneurophysiological analysis could be used to determine the extent, course, and range of nerve system damage in patients with acute TTX poisoning.

• Authors: Dinghua Liu, Jianyu Zhang, Bojun Han, Lang Pen, Dongbai Liu
• Journal: Cell biochemistry and biophysics (Cell Biochem Biophys) Vol. 59 Issue 1 Pg. 13-8 (Jan 2011) ISSN: 1559-0283 [Electronic] United States
• PMID: 20697975 (Publication Type: Journal Article)

Chemical References

• Tetrodotoxin

Topics

• Adult
• Animals
• Electrophysiological Phenomena (drug effects)
• Evoked Potentials, Somatosensory (drug effects)
• Female
• Fishes, Poisonous
• Foodborne Diseases (diagnosis, physiopathology)
• H-Reflex (drug effects)
• Humans
• Male
• Middle Aged
• Neural Conduction (drug effects)
• Tetraodontiformes
• Tetrodotoxin (poisoning)