A novel inhibitor of IL-1 generation, E5090: in vivo inhibitory effect on the generation of IL-1-like factor and on granuloma formation in an air-pouch model.

Abstract

The in vivo production of IL-1-like activity was investigated in the exudate of a rat air-pouch inflammatory model. An inflammatory reaction was induced by LPS injection into the air-pouch. IL-1 activity in the exudate reached the maximum level at 4 h and then rapidly decreased until 8 h after the injection of LPS. Orally administered E5090 and prednisolone dose-dependently inhibited the generation of IL-1 activity. Both compounds also suppressed chronic granuloma formation in parallel with the IL-1 inhibition. On the other hand, indomethacin had no effect on either IL-1 generation or granuloma formation in spite of the complete inhibition of PGE2 generation. These results suggest that E5090 inhibits the production of IL-1-like activity in the exudate and exhibits steroid-like antiinflammatory effects.

• Authors: K Chiba, M Goto, H Shirota
• Journal: Agents and actions. Supplements (Agents Actions Suppl) Vol. 32 Pg. 231-5 ( 1991) ISSN: 0379-0363 [Print] Switzerland
• PMID: 2069092 (Publication Type: Journal Article)

Chemical References

• Acrylates
• Anti-Inflammatory Agents, Non-Steroidal
• Interleukin-1
• Naphthols
• Orosomucoid
• E 5090
• Prednisolone
• Dinoprostone
• Indomethacin

Topics

• Acrylates (pharmacology)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Dinoprostone (metabolism)
• Exudates and Transudates (cytology, metabolism)
• Granuloma (metabolism, prevention & control)
• Indomethacin (pharmacology)
• Interleukin-1 (biosynthesis)
• Male
• Naphthols (pharmacology)
• Orosomucoid (biosynthesis)
• Prednisolone (pharmacology)
• Rats
• Rats, Inbred F344