Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice.

Abstract

AIM:

To investigate the effects of GABA and glycine on analgesia in the central nervous system.

METHODS:

Glycine, taurine, or muscimol was injected with bicuculline into the cistern magna or the lumbar subarachnoidal space in ICR mice. The effects on bicuculline-induced allodynia in a touch-evoked agitation test and on pain threshold index in a hot-plate test were assessed.

RESULTS:

The dosages of the amino acids administered with bicuculline had no effect on motor behavior in conscious mice. Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia. Glycine, taurine, and muscimol all antagonized the effects induced by bicuculline in the hot-plate test, regardless of the administration site.

CONCLUSION:

Glycine, taurine, and muscimol were found to have anti-allodynic and anti-thermal hyperalgesic properties in vivo. These observations suggest an interaction between glycine and GABA receptors during the regulation of antinociception.

• Authors: Il-ok Lee, Eui-sung Lim
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 31 Issue 8 Pg. 907-14 (Aug 2010) ISSN: 1745-7254 [Electronic] United States
• PMID: 20686515 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, GABA
• Receptors, Glycine
• Taurine
• Muscimol
• Glycine
• Bicuculline

Topics

• Animals
• Bicuculline
• Disease Models, Animal
• Glycine (administration & dosage, pharmacology)
• Hot Temperature
• Hyperalgesia (drug therapy, physiopathology)
• Injections
• Injections, Spinal
• Male
• Mice
• Mice, Inbred ICR
• Muscimol (administration & dosage, pharmacology)
• Pain (drug therapy, physiopathology)
• Pain Threshold
• Receptors, GABA (drug effects, metabolism)
• Receptors, Glycine (drug effects, metabolism)
• Taurine (administration & dosage, pharmacology)