[Lymphocyte GRK2 expression of the very elderly with chronic heart failure].

Abstract

OBJECTIVE:

To explore the correlation of lymphocyte G protein-coupled receptor kinases 2 (GRK2) expression of the very elderly with chronic heart failure (HF) and heart ejection fraction (EF).

METHODS:

16 elderly patients with chronic heart failure were divided into 2 groups as following: EF < 45% (n=7), EF > or = 45% (n=9); and health elderly as control (n=8). Lymphocytes were obtained from blood, reverse transcription polymerase chain reaction were used to measure GRK2 mRNA levels.

RESULTS:

Lymphocyte GRK2 mRNA levels of EF < 45% group were higher than that of EF > 45% group, which were greater than that of control.

CONCLUSION:

Elevation of lymphocyte GRK2 levels in HF is associated with heart EF, lymphocytes may provide a surrogate for monitoring cardiac GRK2 in human HF.

• Authors: Wen-qian Gao, Jin-ling Ma, Chun-guang Han, Qiong Wang, Ping Zhu, Ting-shu Yang
• Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology (Zhongguo Ying Yong Sheng Li Xue Za Zhi) Vol. 26 Issue 2 Pg. 207-9 (May 2010) ISSN: 1000-6834 [Print] China
• PMID: 20684281 (Publication Type: Journal Article)

Chemical References

• RNA, Messenger
• GRK2 protein, human
• G-Protein-Coupled Receptor Kinase 2

Topics

• Aged, 80 and over
• Chronic Disease
• G-Protein-Coupled Receptor Kinase 2 (genetics, metabolism)
• Heart Failure (blood, physiopathology)
• Humans
• Lymphocytes (metabolism)
• Male
• RNA, Messenger (genetics, metabolism)
• Stroke Volume (physiology)