Abstract | BACKGROUND: METHODS: Male Wistar rats (n = 56) were divided into seven groups, i.e. control, diabetic, PG-treated control, PG (single- and multiple-dose)-treated diabetic, and sodium salicylate-treated control and diabetics. For induction of diabetes, STZ was injected i.p. at a single dose of 60 mg/kg. PG was orally administered at a dose of 10 mg/kg once and/or on alternate days for 8 weeks; 1 week after diabetes induction. After two months, hyperalgesia was assessed using standard formalin and hot tail immersion tests. Meanwhile, markers of oxidative stress in brain were measured. One-way analysis of variance was used for statistical analysis of the data. RESULTS: CONCLUSION: These results clearly suggest that PG prevents diabetic neuropathic hyperalgesia through attenuation of oxidative stress.
|
Authors | Mohammadali Mirshekar, Mehrdad Roghani, Mohsen Khalili, Tourandokht Baluchnejadmojarad, Saiedeh Arab Moazzen |
Journal | Iranian biomedical journal
(Iran Biomed J)
2010 Jan-Apr
Vol. 14
Issue 1-2
Pg. 33-9
ISSN: 2008-823X [Electronic] Iran |
PMID | 20683496
(Publication Type: Journal Article)
|
Chemical References |
- Anthocyanins
- Free Radical Scavengers
- Nitrites
- Thiobarbituric Acid Reactive Substances
- pelargonidin
- Superoxide Dismutase
|
Topics |
- Administration, Oral
- Animals
- Anthocyanins
(pharmacology)
- Diabetes Mellitus, Experimental
(drug therapy, metabolism)
- Diabetic Neuropathies
(drug therapy, metabolism)
- Free Radical Scavengers
(pharmacology)
- Hyperalgesia
(drug therapy, metabolism)
- Male
- Nitrites
(metabolism)
- Oxidative Stress
(drug effects)
- Pain Measurement
- Rats
- Rats, Wistar
- Superoxide Dismutase
(metabolism)
- Thiobarbituric Acid Reactive Substances
(metabolism)
|