Abstract |
One small previous study found that praziquantel reduced hookworm infection. In this study, 607 subjects were enrolled in a longitudinal study. At enrollment and every 3 months for 18 months, three stool samples were collected, and the intensity of infection with Schistosoma japonicum and soil-transmitted helminths (STHs) was quantified. All subjects were treated with 60 mg/kg praziquantel at baseline. Three months post-treatment, the percent of subjects who were hookworm-infected decreased to 46.5% from 61% at baseline. The putative cure rate was 23.7%. The 95% confidence interval around the change in hookworm egg counts from baseline to 6 and 12 months post-treatment was negative and did not include zero. The percent reduction in hookworm egg counts from baseline to 3 months post-treatment was 40.8%. Praziquantel treatment did not decrease the infection intensity of STHs. Control programs using praziquantel may have the added benefit of reducing hookworm infection and anemia in areas of coendemnicity.
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Authors | Julia G Shaw, Nitin Aggarwal, Luz P Acosta, Mario A Jiz, Hai-Wei Wu, Tjalling Leenstra, Hannah M Coutinho, Remigio M Olveda, Jonathan D Kurtis, Stephen T McGarvey, Jennifer F Friedman |
Journal | The American journal of tropical medicine and hygiene
(Am J Trop Med Hyg)
Vol. 83
Issue 2
Pg. 416-21
(Aug 2010)
ISSN: 1476-1645 [Electronic] United States |
PMID | 20682892
(Publication Type: Journal Article)
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Chemical References |
- Anthelmintics
- Praziquantel
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Topics |
- Adolescent
- Adult
- Animals
- Anthelmintics
(therapeutic use)
- Child
- Feces
(parasitology)
- Female
- Hookworm Infections
(drug therapy, epidemiology)
- Humans
- Longitudinal Studies
- Male
- Parasite Egg Count
- Parrots
- Philippines
(epidemiology)
- Praziquantel
(therapeutic use)
- Schistosoma japonicum
- Schistosomiasis japonica
(drug therapy, epidemiology)
- Young Adult
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