Diagnostic efficacy of gadoxetic acid-enhanced MRI in the detection of hepatocellular carcinomas: comparison with gadopentetate dimeglumine.

Abstract

This study compared the efficacy of gadoxetic acid-enhanced MRI and gadopentetate dimeglumine-enhanced MRI in the detection of small hepatocellular carcinoma (HCC). Both MRI techniques were performed on 43 patients with a total of 59 HCCs (size range, 0.5-2.0 cm), with a mean interval between the two MRI studies of 3 days (range, 2-7 days). Two observers reviewed both data sets in consensus. Diagnostic accuracy and sensitivity were evaluated using the alternative-free response receiver operator characteristic (ROC) method. The gadoxetic acid set showed a trend toward increased area under the ROC curve (Az value = 0.958) compared with the gadopentetate dimeglumine set (Az value = 0.927), but the difference was not significant (p = 0.362). The sensitivity of the gadoxetic acid set (n = 51, 86.4%) was significantly higher than that of the gadopentetate dimeglumine set (n = 38, 64.4%) (p = 0.0001). Gadoxetic acid-enhanced MRI is a more sensitive diagnostic tool for detection of HCC than gadopentetate dimeglumine-enhanced MRI.

• Authors: G Park, Y K Kim, C S Kim, H C Yu, S B Hwang
• Journal: The British journal of radiology (Br J Radiol) Vol. 83 Issue 996 Pg. 1010-6 (Dec 2010) ISSN: 1748-880X [Electronic] England
• PMID: 20682591 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media
• Gadolinium DTPA

Topics

• Adult
• Aged
• Carcinoma, Hepatocellular (diagnosis)
• Contrast Media
• Female
• Gadolinium DTPA
• Humans
• Liver Neoplasms (diagnosis)
• Magnetic Resonance Imaging (methods)
• Male
• Middle Aged
• ROC Curve
• Retrospective Studies
• Sensitivity and Specificity