Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco Dependence.

Abstract

The aim of this study was to determine whether standard treatments for Tobacco Dependence affect smoking-induced changes in intrasynaptic dopamine (DA) concentration. Forty-three otherwise healthy adult cigarette smokers (10 to 40 cigarettes per day) were treated with either practical group counseling (PGC) psychotherapy (n=14), bupropion HCl (n=14), or matching pill placebo (n=15) (random assignment) for 8 weeks. Before and after treatment, each subject underwent a bolus-plus-continuous-infusion (11)C-raclopride positron emission tomography (PET) scanning session, during which he or she smoked a regular cigarette. The PET scanning outcome measure of interest was percent change in smoking-induced (11)C-raclopride binding potential (BP(ND)) in the ventral caudate/nucleus accumbens (VCD/NAc), as an indirect measure of DA release. Although the entire study sample had a smaller mean smoking-induced reduction in VCD/NAc BP(ND) after treatment (compared to before treatment), this change was highly correlated with smaller total cigarette puff volumes (and not other treatment variables). These data indicate that smoking-induced DA release is dose-dependent, and is not significantly affected by reductions in daily smoking levels or treatment type.

• Authors: Arthur L Brody, Edythe D London, Richard E Olmstead, Zoe Allen-Martinez, Stephanie Shulenberger, Matthew R Costello, Anna L Abrams, David Scheibal, Judah Farahi, Steven Shoptaw, Mark A Mandelkern
• Journal: Psychiatry research (Psychiatry Res) Vol. 183 Issue 3 Pg. 218-24 (Sep 30 2010) ISSN: 0165-1781 [Print] Ireland
• PMID: 20682457 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: Published by Elsevier Ireland Ltd.

Chemical References

• Dopamine Antagonists
• Dopamine Uptake Inhibitors
• Bupropion
• Raclopride
• Dopamine

Topics

• Adult
• Aged
• Analysis of Variance
• Bupropion (therapeutic use)
• Dopamine (metabolism)
• Dopamine Antagonists (pharmacokinetics)
• Dopamine Uptake Inhibitors (therapeutic use)
• Double-Blind Method
• Female
• Humans
• Magnetic Resonance Imaging (methods)
• Male
• Middle Aged
• Positron-Emission Tomography (methods)
• Raclopride (pharmacokinetics)
• Smoking (metabolism, psychology)
• Statistics as Topic
• Synapses (diagnostic imaging, metabolism)
• Tobacco Use Disorder (diagnostic imaging, drug therapy)
• Young Adult