The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases.

Abstract

Inflammatory response represents one of the first immune processes following injury. It is characterized by the production of various molecules that initiate the recruitment of immune cells to the lesion sites, including in the brain. Accordingly, in acute brain trauma, such as stroke, as well as during chronic affections like multiple sclerosis or Alzheimer's disease, inflammation occurs in order to "clean up" the lesion and to limit its area. Nevertheless, prolonged and sustained inflammation may have cytotoxic effects, aggravating the incidence and the severity of the disease. Among molecules produced during inflammation associated to neuronal death, monocyte chemoattractant proteins (MCPs) seem to be particularly important. This review will focus on the current knowledge about one of the MCPs, CCL2, and its cognate receptor, CCR2, both expressed in physiological conditions and during neurodegenerative diseases.

• Authors: Grégory Conductier, Nicolas Blondeau, Alice Guyon, Jean-Louis Nahon, Carole Rovère
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 224 Issue 1-2 Pg. 93-100 (Jul 27 2010) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 20681057 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: (c) 2010 Elsevier B.V. All rights reserved.

Chemical References

• CCL2 protein, human
• CCR2 protein, human
• Chemokine CCL2
• Receptors, CCR2

Topics

• Alzheimer Disease (immunology, metabolism, pathology)
• Animals
• Brain (immunology, metabolism, pathology)
• Chemokine CCL2 (biosynthesis, genetics, physiology)
• Chemotaxis, Leukocyte (immunology)
• Humans
• Multiple Sclerosis (immunology, metabolism, pathology)
• Receptors, CCR2 (biosynthesis, genetics, physiology)
• Stroke (immunology, metabolism, pathology)