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Selenium- and tellurium-containing multifunctional redox agents as biochemical redox modulators with selective cytotoxicity.

Abstract
Various human diseases, including different types of cancer, are associated with a disturbed intracellular redox balance and oxidative stress (OS). The past decade has witnessed the emergence of redox-modulating compounds able to utilize such pre-existing disturbances in the redox state of sick cells for therapeutic advantage. Selenium- and tellurium-based agents turn the oxidizing redox environment present in certain cancer cells into a lethal cocktail of reactive species that push these cells over a critical redox threshold and ultimately kill them through apoptosis. This kind of toxicity is highly selective: normal, healthy cells remain largely unaffected, since changes to their naturally low levels of oxidizing species produce little effect. To further improve selectivity, multifunctional sensor/effector agents are now required that recognize the biochemical signature of OS in target cells. The synthesis of such compounds provides interesting challenges for chemistry in the future.
AuthorsVincent Jamier, Lalla A Ba, Claus Jacob
JournalChemistry (Weinheim an der Bergstrasse, Germany) (Chemistry) Vol. 16 Issue 36 Pg. 10920-8 (Sep 24 2010) ISSN: 1521-3765 [Electronic] Germany
PMID20677196 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Antioxidants
  • Cytotoxins
  • Metalloporphyrins
  • Selenium
  • Tellurium
Topics
  • Antineoplastic Agents (chemistry, pharmacology, therapeutic use)
  • Antioxidants (chemistry, pharmacology, therapeutic use)
  • Apoptosis (drug effects)
  • Cell Line, Tumor
  • Cytotoxins (chemistry, pharmacology)
  • Humans
  • Metalloporphyrins (chemistry, pharmacology, therapeutic use)
  • Oxidation-Reduction (drug effects)
  • Oxidative Stress (drug effects)
  • Selenium (chemistry, pharmacology, therapeutic use)
  • Tellurium (chemistry, pharmacology, therapeutic use)

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