Abstract | BACKGROUND: The aim of the present study was to determine the mechanisms underlying Type 2 diabetes remission after gastric bypass (GBP) surgery by characterizing the short- and long-term changes in hormonal determinants of blood glucose. METHODS: RESULTS: The decrease in fasting glucose (r = 0.724) and insulin (r = 0.576) was associated with weight loss up to 12 months after GBP. In contrast, the blunted incretin effect (calculated at 22%) that improved at 1 month remained unchanged with further weight loss at 6 (52%) and 12 (52%) months. The blunted incretin ( GLP-1 and GIP) levels, early phase insulin secretion, and other parameters of β-cell function ( amylin, proinsulin/ insulin) followed the same pattern, with rapid improvement at 1 month that remained unchanged at 1 year. CONCLUSIONS: The data suggest that weight loss and incretins may contribute independently to improved glucose levels in the first year after GBP surgery.
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Authors | Mousumi Bose, Julio Teixeira, Blanca Olivan, Baani Bawa, Sara Arias, Sriram Machineni, F Xavier Pi-Sunyer, Philipp E Scherer, Blandine Laferrère |
Journal | Journal of diabetes
(J Diabetes)
Vol. 2
Issue 1
Pg. 47-55
(Mar 2010)
ISSN: 1753-0407 [Electronic] Australia |
PMID | 20676394
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adiponectin
- Blood Glucose
- Incretins
- Insulin
- Leptin
- Glucagon-Like Peptide 1
- Glucagon
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Topics |
- Adiponectin
(blood)
- Adult
- Blood Glucose
(drug effects, metabolism)
- Diabetes Mellitus, Type 2
(complications)
- Fasting
- Female
- Gastric Bypass
- Glucagon
(blood)
- Glucagon-Like Peptide 1
(blood)
- Glucose Tolerance Test
- Humans
- Incretins
(therapeutic use)
- Insulin
(blood, metabolism)
- Insulin Secretion
- Leptin
(blood)
- Middle Aged
- Obesity, Morbid
(complications, surgery)
- Postoperative Period
- Stomach
(surgery)
- Weight Loss
(physiology)
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