Treatment of oral florid papillomatosis with systemic administration of photocarcinorin: an effective photodynamic therapy.

Abstract

OBJECTIVES:

To evaluate the safety and effect of systemic administration of photosensitizer Photocarcinorin (PsD-007) in the treatment of oral florid papillomatosis (OFP).

BACKGROUND:

OFP is a rare and refractory disease characterized by multiple papillomatous lesions. The outcomes of many methods for OFP are not satisfactory.

MATERIALS AND METHODS:

Photosensitizer Photocarcinorin (5 mg/kg) was intravenously injected into a 59-year-old woman with widespread OFP, and the lesions were irradiated for 10 min by using a 635-nm laser beam of 177 mW/cm(2) intensity and 106.2 J/cm(2) energy density. The therapy was performed once a month for 3 months in total.

RESULTS:

After three courses, the small lesions disappeared, and the larger ones were reduced by ≥80%. The adverse effects were minimal.

CONCLUSIONS:

Systemic PDT is an effective and successful treatment modality for OFP, especially in elderly patients.

• Authors: Yuan-gang Lu, Jin-jin Wu, Xia Lei, Tang-you Zhu, Yang He, Ling Chen, Qiong-hui Cheng
• Journal: Photomedicine and laser surgery (Photomed Laser Surg) Vol. 28 Issue 6 Pg. 831-3 (Dec 2010) ISSN: 1557-8550 [Electronic] United States
• PMID: 20673139 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hematoporphyrins
• Photosensitizing Agents
• photocarcinorin

Topics

• Female
• Hematoporphyrins (therapeutic use)
• Humans
• Middle Aged
• Mouth Neoplasms (drug therapy)
• Papilloma (drug therapy)
• Photochemotherapy
• Photosensitizing Agents (therapeutic use)