The protective effects of (4R)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on chemically-induced acute liver injury.

Abstract	The effects of SA3443, a novel cyclic disulfide compound, on acute liver injuries induced by carbon tetrachloride (CCl4), D-galactosamine and DL-ethionine were studied in rats or mice. SA3443 (100-300 mg/kg, p.o.) significantly suppressed the increases of serum transaminase activity and liver triglyceride content in the CCl4 or DL-ethionine-induced model. Furthermore, SA3443 (300 mg/kg, p.o.) clearly reduced the formation of hepatic lipid peroxide in CCl4-treated rats. These results indicate that SA3443 protects the liver against acute liver injury.
Authors	N Ishida, K Nakata, M Tanaka, K Takase, S Mita
Journal	Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 55 Issue 2 Pg. 275-8 (Feb 1991) ISSN: 0021-5198 [Print] Japan
PMID	2067142 (Publication Type: Journal Article)
Chemical References	Azocines Disulfides Lipid Peroxides Triglycerides SA 3443 Galactosamine Carbon Tetrachloride Aspartate Aminotransferases Alanine Transaminase Ethionine
Topics	Alanine Transaminase (blood) Animals Aspartate Aminotransferases (blood) Azocines (pharmacology) Carbon Tetrachloride Chemical and Drug Induced Liver Injury Disulfides (pharmacology) Ethionine Galactosamine Lipid Peroxides (metabolism) Liver Diseases (prevention & control) Male Rats Rats, Inbred Strains Triglycerides (metabolism)

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