Werner's syndrome combined with quintuplicate malignant tumors: a case report and review of literature data.

Abstract

The authors report a case of Werner's syndrome complicated by quintuplicate malignancy, and review the literature data. Four malignancies occurred synchronously in the case: osteosarcoma of the left distal tibia, malignant melanoma of the left plantar region, gastric cancer, pulmonary coin lesion. The osteosarcoma and malignant melanoma were treated by below-knee amputation and the gastric cancer by palliative surgery; the pulmonary coin lesion did not respond to cisplatin chemotherapy. It was difficult to treat the multiple primary cancer curatively, and patient died of respiratory failure due to a brain tumor seven months after surgery. The postmortem examination revealed a papillary carcinoma of the thyroid gland and a leiomyosarcoma of the lung. In some cases of Werner's syndrome, attention should be paid to the concurrent occurrence of multiple primary malignant neoplasms.

• Authors: H Tsuchiya, K Tomita, M Ohno, M Inaoki, A Kawashima
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 21 Issue 2 Pg. 135-42 (Apr 1991) ISSN: 0368-2811 [Print] England
• PMID: 2067129 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Humans
• Male
• Middle Aged
• Neoplasms, Multiple Primary (etiology, pathology)
• Werner Syndrome (complications)