Abstract | CONTEXT:
Chordoma is a rare, notochordal tumor with a characteristic histomorphology and immunohistochemical profile. At times, it presents a diagnostic challenge, especially in small biopsies. Brachyury, a nuclear transcription factor, is a recently described immunohistochemical marker for diagnosing chordomas. OBJECTIVE: DESIGN: Fifty-one axial chordomas, accessioned during a 10-year period, and 58 nonchordomatous tumors were subjected to brachyury staining by immunohistochemistry. RESULTS: The 51 chordomas occurred in 36 men and 15 women. Sitewise, 34 cases (66.7%) occurred in the sacrococcyx, 9 (17.6%) in the spine, and 8 (15.7%) in the skull base. Histologically, 34 cases (66.7%) were classical chordomas, 13 cases (25.5%) had a dominant chondroid component, and 2 cases each (3.9%) were chondroid chordomas and dedifferentiated chordomas, respectively. Brachyury staining was positive in 46 of the 51 chordomas (90.2%) and negative in all 58 nonchordomatous tumors. The dedifferentiated area in 2 chordomas was negative for brachyury staining. Fourteen of 15 chordomas with chondroid component showed positive brachyury staining. Immunohistochemical expression of other markers, included cytokeratin (positive in 23 of 23 cases; 100%), epithelial membrane antigen (positive in 22 of 22 cases; 100%) and S100 protein (positive in 18 of 21 cases; 85.7%). CONCLUSION:
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Authors | Nirmala A Jambhekar, Bharat Rekhi, Kiran Thorat, Rajesh Dikshit, Manish Agrawal, Ajay Puri |
Journal | Archives of pathology & laboratory medicine
(Arch Pathol Lab Med)
Vol. 134
Issue 8
Pg. 1181-7
(Aug 2010)
ISSN: 1543-2165 [Electronic] United States |
PMID | 20670140
(Publication Type: Journal Article, Validation Study)
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Chemical References |
- Biomarkers, Tumor
- Fetal Proteins
- T-Box Domain Proteins
- Brachyury protein
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Topics |
- Biomarkers, Tumor
(metabolism)
- Chordoma
(diagnosis, metabolism)
- Female
- Fetal Proteins
(metabolism)
- Humans
- Immunohistochemistry
- Male
- Notochord
(metabolism, pathology)
- Skull Base Neoplasms
(diagnosis, metabolism)
- Spinal Neoplasms
(diagnosis, metabolism)
- T-Box Domain Proteins
(metabolism)
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