Abstract | OBJECTIVE: METHODS: This was a randomized, examiner-blind, two-arm parallel group, three-day clinical study with seventy-nine subjects, stratified based on baseline tooth sensitivity. Tooth sensitivity was determined through subject responses to both evaporative (Schiff and Visual Analogue Scale [VAS]) and tactile stimuli (Yeaple probe), prior to and immediately after subjects self-applied a single pea-sized amount of either the test or control dentifrice to qualifying sensitive teeth, massaging the toothpaste onto the sensitive area for one minute. Tooth sensitivity was further assessed in response to the same stimuli after subjects brushed twice daily for an additional three days. Subject assessments were performed by the same examiner throughout the study. RESULTS: Seventy-nine subjects completed this clinical study. Both subject groups exhibited reductions in dentin hypersensitivity directly after a single dab-on application. These reductions were significant across all measures for the test dentifrice. Between-treatment analyses showed the test dentifrice to be significantly better at relieving subjects' sensitivity across all measures (Schiff p = 0.0003, tactile p = 0.0003, and VAS p = 0.0077) compared to the control. After the additional three days of twice-daily brushing, between-treatment analyses showed the test dentifrice to be significantly better at relieving subjects' sensitivity across all measures (Schiff p = 0.0102, tactile p = 0.0493, and VAS p = 0.0067) than the control dentifrice. CONCLUSION:
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Authors | Stephen Mason, Nathan Hughes, Farzana Sufi, Linda Bannon, Brenda Maggio, Mairead North, Jon Holt |
Journal | The Journal of clinical dentistry
(J Clin Dent)
Vol. 21
Issue 2
Pg. 42-8
( 2010)
ISSN: 0895-8831 [Print] United States |
PMID | 20669815
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acetates
- Dentifrices
- Dentin Desensitizing Agents
- strontium acetate
- Silicon Dioxide
- Sodium Fluoride
- Fluorides
- Strontium
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Topics |
- Acetates
(therapeutic use)
- Administration, Topical
- Adult
- Air
- Dentifrices
(therapeutic use)
- Dentin Desensitizing Agents
(therapeutic use)
- Dentin Sensitivity
(classification, drug therapy)
- Double-Blind Method
- Female
- Fluorides
(administration & dosage, therapeutic use)
- Follow-Up Studies
- Humans
- Male
- Physical Stimulation
- Silicon Dioxide
- Sodium Fluoride
(administration & dosage, therapeutic use)
- Strontium
(therapeutic use)
- Toothbrushing
(instrumentation)
- Touch
- Treatment Outcome
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