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The role of fluoride and casein phosphopeptide/amorphous calcium phosphate in the prevention of erosive/abrasive wear in an in vitro model using hydrochloric acid.

AbstractOBJECTIVE:
To investigate the effect of various fluoride compounds and casein phosphopeptide/amorphous calcium phosphate (CPP-ACP) on the reduction of erosive/abrasive tooth wear.
METHODS:
Forty enamel samples were prepared from bovine lower incisors, stratified and allocated to 4 groups (1-4). Samples in group 1 remained untreated and served as negative controls. The test samples were treated for 2 min/day as follows: group 2 amine/sodium fluoride gel (pH 4.8; 12,500 ppm), group 3 sodium fluoride gel (pH 7.1; 12,500 ppm) and group 4 CPP-ACP-containing mousse. De- and remineralization cycling was performed for 20 days with 6 erosive attacks for 20 s with HCl (pH 3.0) per day. Samples were stored in artificial saliva between cycles and overnight. Toothbrushing (15 s; 60 strokes/min; load 2.5 N) with a toothpaste slurry was performed each day before the first and 1 h after the last erosive exposure. Tooth wear was measured by comparing baseline surface profiles with the corresponding posttreatment profiles.
RESULTS:
Tooth wear was significantly reduced in groups 2 and 3 compared with group 1, while the enamel loss of group 4 was not significantly lower compared to the negative control group 1. Between the fluoride groups 2 and 3, no significant difference in tooth wear was recorded.
CONCLUSION:
Erosive/abrasive tooth wear under the conditions used could be reduced significantly by the daily application of fluoride gels, irrespective of the fluoride compound, while the application of CPP-ACP-containing mousse was less effective.
AuthorsFlorian J Wegehaupt, T Attin
JournalCaries research (Caries Res) Vol. 44 Issue 4 Pg. 358-63 ( 2010) ISSN: 1421-976X [Electronic] Switzerland
PMID20668377 (Publication Type: Comparative Study, Journal Article)
CopyrightCopyright 2010 S. Karger AG, Basel.
Chemical References
  • Acids
  • Calcium Phosphates
  • Cariostatic Agents
  • Caseins
  • Fluorides, Topical
  • casein phosphopeptide-amorphous calcium phosphate nanocomplex
Topics
  • Acids (adverse effects)
  • Administration, Topical
  • Animals
  • Calcium Phosphates (therapeutic use)
  • Cariostatic Agents (therapeutic use)
  • Caseins (therapeutic use)
  • Cattle
  • Dental Enamel (drug effects, pathology)
  • Fluorides, Topical (therapeutic use)
  • Tooth Erosion (etiology, pathology, prevention & control)
  • Tooth Wear (etiology, pathology, prevention & control)
  • Toothbrushing (adverse effects)

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