Abstract | BACKGROUND: This study was undertaken to evaluate the possible effects of different daily doses of black tea intake on certain oxidative stress, inflammatory and metabolic biomarkers in patients with type 2 diabetes mellitus (T2DM). METHODS: Forty-six patients with known T2DM were randomly assigned either to the test (n = 23, 57.0 +/- 7.9 years) or the control (n = 23, 55.4 +/- 8.3 years) group. Following a one-week 'run-in' period, the test group received 150, 300, 450 and 600 ml of black tea extract (BTE) during the weeks 1, 2, 3 and 4, respectively. The control group received 150 ml BTE a day throughout the intervention period. Dietary, anthropometric and biochemical assessments were performed at the end of each week. FINDINGS: Serum total antioxidant capacity was enhanced similarly in both test and control groups. However, daily intake of 2 cups of BTE by the test group showed a suppressing effect on serum malondialdehyde. Serum C-reactive protein significantly decreased and glutathione levels increased following the intake of 4 cups (600 ml) of BTE a day. CONCLUSION: Regular intake of BTE had anti-oxidative and anti-inflammatory effects in patients with T2DM. These findings may, to some extent, explain the mechanisms underlying the protective effects of drinking tea against cardiovascular disease.
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Authors | Tirang R Neyestani, Nastaran Shariatzade, Ali Kalayi, A'azam Gharavi, Niloufar Khalaji, Monireh Dadkhah, Telma Zowghi, Homa Haidari, Sakineh Shab-bidar |
Journal | Annals of nutrition & metabolism
(Ann Nutr Metab)
Vol. 57
Issue 1
Pg. 40-9
( 2010)
ISSN: 1421-9697 [Electronic] Switzerland |
PMID | 20668372
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | 2010 S. Karger AG, Basel. |
Chemical References |
- Antioxidants
- Biomarkers
- Plant Extracts
- Tea
- Malondialdehyde
- C-Reactive Protein
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Topics |
- Antioxidants
(metabolism)
- Biomarkers
- C-Reactive Protein
(drug effects)
- Camellia sinensis
(chemistry)
- Diabetes Mellitus, Type 2
(drug therapy)
- Female
- Humans
- Male
- Malondialdehyde
(blood)
- Middle Aged
- Oxidative Stress
(drug effects)
- Plant Extracts
(pharmacology)
- Tea
(chemistry)
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