Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: Japanese patients with type 2 diabetes (n = 254, 185 with normoalbuminuria and 69 with microalbuminuria) were enrolled in an observational follow-up study. The associations of urinary type IV collagen with progression of nephropathy and annual decline in estimated glomerular filtration rate (eGFR) were evaluated. RESULTS: At baseline, urinary type IV collagen levels were higher in patients with microalbuminuria than in those with normoalbuminuria and correlated with urinary beta(2)-microglobulin (beta = 0.57, P < 0.001), diastolic blood pressure (beta = 0.15, P < 0.01), eGFR (beta = 0.15, P < 0.01), and urinary albumin excretion rate (beta = 0.13, P = 0.01) as determined by multivariate regression analysis. In the follow-up study (median duration 8 years), urinary type IV collagen level at baseline was not associated with progression to a higher stage of diabetic nephropathy. However, the level of urinary type IV collagen inversely correlated with the annual decline in eGFR (gamma = -0.34, P < 0.001). Multivariate regression analysis identified urinary type IV collagen, eGFR at baseline, and hypertension as factors associated with the annual decline in eGFR. CONCLUSIONS: Our results indicate that high urinary excretion of type IV collagen is associated with deterioration of renal function in type 2 diabetic patients without overt proteinuria.
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Authors | Shin-ichi Araki, Masakazu Haneda, Daisuke Koya, Keiji Isshiki, Shinji Kume, Toshiro Sugimoto, Hiromichi Kawai, Yoshihiko Nishio, Atsunori Kashiwagi, Takashi Uzu, Hiroshi Maegawa |
Journal | Diabetes care
(Diabetes Care)
Vol. 33
Issue 8
Pg. 1805-10
(Aug 2010)
ISSN: 1935-5548 [Electronic] United States |
PMID | 20668153
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Collagen Type IV
(urine)
- Diabetes Mellitus, Type 2
(physiopathology, urine)
- Diabetic Nephropathies
(pathology, urine)
- Female
- Glomerular Filtration Rate
- Humans
- Kidney
(pathology)
- Male
- Middle Aged
- Proteinuria
(physiopathology)
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