Intercellular adhesion molecule inhibitors as potential therapy for refractory uveitic macular edema.

Abstract

PURPOSE:

To describe the bioactivity of an intercellular adhesion molecule inhibitor (efalizumab) in a patient with refractory uveitic macular edema.

METHODS:

A 55-year-old man presented with idiopathic autoimmune uveitis and associated macular edema, which could not be controlled by regional and systemic corticosteroid and selected immunomodulatory therapy. Efalizumab was administered as subcutaneous injections.

RESULTS:

After 37 weekly injections of efalizumab, the uveitic macular edema was successfully eliminated. Six months following discontinuation of efalizumab, there were no signs of recurrent inflammation.

CONCLUSION:

Further investigation of the role of intercellular adhesion molecule inhibitors in the management of uveitic macular edema is indicated.

• Authors: Jianmin Wang, Mohamed Ibrahim, Peykan Turkcuoglu, Elham Hatef, Afsheen Khwaja, Roomasa Channa, Diana V Do, Quan Dong Nguyen
• Journal: Ocular immunology and inflammation (Ocul Immunol Inflamm) Vol. 18 Issue 5 Pg. 395-8 (Oct 2010) ISSN: 1744-5078 [Electronic] England
• PMID: 20666682 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Cell Adhesion Molecules
• efalizumab

Topics

• Antibodies, Monoclonal (administration & dosage)
• Antibodies, Monoclonal, Humanized
• Autoimmune Diseases (complications)
• Cell Adhesion Molecules (antagonists & inhibitors)
• Humans
• Injections, Subcutaneous
• Macular Edema (diagnosis, drug therapy, etiology)
• Male
• Middle Aged
• Tomography, Optical Coherence
• Treatment Outcome
• Uveitis, Posterior (complications)