Abstract | BACKGROUND: METHODS: Eight RYGB patients with hypoglycemic syndrome had insulin secretion rates determined during a 240-min graded intravenous glucose infusion. They were compared to 34 nondiabetic, nonsurgical individuals who were divided based on their insulin sensitivity status as measured by the insulin suppression test: insulin-sensitive (n = 8), insulin intermediate (n = 7), and insulin-resistant (n = 19). RESULTS: RYGB patients had insulin concentrations and HOMA-IR similar to the insulin-sensitive reference group. In addition, integrated insulin secretion rates were comparable to the insulin-sensitive group and significantly lower than the insulin intermediate (p <or= 0.046) and insulin-resistant groups (p <or= 0.001). Pancreatic beta-cell sensitivity to glucose (slope relating glucose and ISR) was lowest in the RYGB group (p <or= 0.04). CONCLUSIONS: Patients with hypoglycemic syndrome post-RYGB do not have generalized hypersecretion of insulin and appear to have appropriate insulin secretion rate in response to intravenous glucose.
|
Authors | Sun H Kim, Fahim Abbasi, Cindy Lamendola, Gerald M Reaven, Tracey McLaughlin |
Journal | Obesity surgery
(Obes Surg)
Vol. 20
Issue 8
Pg. 1110-6
(Aug 2010)
ISSN: 1708-0428 [Electronic] United States |
PMID | 20665189
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Chemical References |
|
Topics |
- Adult
- Area Under Curve
- Female
- Gastric Bypass
(adverse effects)
- Glucose
(administration & dosage, metabolism)
- Humans
- Hyperinsulinism
(etiology)
- Hypoglycemia
(etiology, metabolism)
- Insulin
(metabolism)
- Insulin Resistance
(physiology)
- Insulin Secretion
- Insulin-Secreting Cells
(physiology)
- Male
- Middle Aged
- Obesity, Morbid
(surgery)
|