HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Macrolides and community-acquired pneumonia: is quorum sensing the key?

Abstract
Combination therapy with two antimicrobial agents is superior to monotherapy in severe community-acquired pneumonia, and recent data suggest that addition of a macrolide as the second antibiotic might be superior to other combinations. This observation requires confirmation in a randomised control trial, but this group of antibiotics have pleiotropic effects that extend beyond bacterial killing. Macrolides inhibit bacterial cell-to-cell communication or quorum sensing, which not only might be an important mechanism of action for these drugs in severe infections but may also provide a novel target for the development of new anti-infective drugs.
AuthorsMatt P Wise, David W Williams, Michael A O Lewis, Paul J Frost
JournalCritical care (London, England) (Crit Care) Vol. 14 Issue 4 Pg. 181 ( 2010) ISSN: 1466-609X [Electronic] England
PMID20663182 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Macrolides
Topics
  • Anti-Bacterial Agents (administration & dosage, therapeutic use)
  • Community-Acquired Infections (drug therapy, microbiology)
  • Drug Therapy, Combination
  • Humans
  • Macrolides (administration & dosage, therapeutic use)
  • Pneumonia, Bacterial (drug therapy, microbiology)
  • Quorum Sensing (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: