Abstract | BACKGROUND: METHODS: To explore whether HBGAs or certain viral genotypes are associated with asymptomatic norovirus infections in a pediatric population in Nicaragua, we investigated 163 children ≤5 years of age, without a recent history of diarrhea (≤10 days). RESULTS: Asymptomatic norovirus infections were observed in 11.7% (19/163), with children ≤6 months of age being most frequently infected (16%). Of the 19 norovirus-positive children, 4 (21%) and 10 (53%) were infected with genogroups GI and GII, respectively, and 4 children (21%) were infected with viruses of both genogroups. Most children had ≥10 viral genomes per gram of feces. Nucleotide sequence analysis (15/19) revealed uncommon genotypes, such as, GII.7 (n = 5) and GII.2 (n = 3). An interesting observation was the low frequency of norovirus GII.4 strains among the asymptomatic children. AB blood type, Lewis a (Le) phenotype and nonsecretor genotype (sese) were not found among the asymptomatic children, but they occurred in population controls. CONCLUSIONS: Frequency of asymptomatic norovirus infections was similar to that observed in symptomatic children from Nicaragua. Norovirus GII.2 and GII.7 were frequently detected but the globally dominating GII.4 was infrequent. Host genetic factors previously observed to be associated with protection against symptomatic norovirus infection were not found in this study.
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Authors | Filemon Bucardo, Johan Nordgren, Beatrice Carlsson, Elin Kindberg, Margarita Paniagua, Roland Möllby, Lennart Svensson |
Journal | The Pediatric infectious disease journal
(Pediatr Infect Dis J)
Vol. 29
Issue 10
Pg. 934-9
(Oct 2010)
ISSN: 1532-0987 [Electronic] United States |
PMID | 20657344
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Asymptomatic Infections
(epidemiology)
- Blood Group Antigens
(analysis)
- Caliciviridae Infections
(epidemiology, virology)
- Child, Preschool
- Feces
(virology)
- Female
- Genotype
- Humans
- Infant
- Infant, Newborn
- Male
- Nicaragua
- Norovirus
(classification, genetics, isolation & purification, pathogenicity)
- Prevalence
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