Rhabdomyosarcomatous differentiation in a neuroblastoma: a potential pitfall in the cytologic diagnosis of small round-cell tumors of childhood.

Abstract	Rhabdomyoblasts demonstrating immunoreactivity for muscle-specific actin, desmin, and myoglobin were identified in smears obtained by aspiration from a large retroperitoneal mass in a 14-mo-old girl. Following a tentative diagnosis of a rhabdomyogenous neoplasm, retroperitoneal exploration and adrenalectomy demonstrated a stromal poor neuroblastoma with extensive rhabdomyogenous differentiation. The presence of a subpopulation of rhabdomyoblasts was not diagnostic of rhabdomyosarcoma when obtained by fine-needle aspiration from a retroperitoneal tumor composed predominantly of primitive small round cells.
Authors	L J Layfield, B J Glasgow
Journal	Diagnostic cytopathology (Diagn Cytopathol) Vol. 7 Issue 2 Pg. 193-7 ( 1991) ISSN: 8755-1039 [Print] United States
PMID	2065576 (Publication Type: Case Reports, Journal Article)
Chemical References	Biomarkers, Tumor
Topics	Adrenal Gland Neoplasms (diagnosis, pathology) Biomarkers, Tumor Biopsy, Needle Diagnosis, Differential Female Humans Immunohistochemistry Infant Neuroblastoma (diagnosis, pathology) Rhabdomyosarcoma (diagnosis, pathology)

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