Long-term outcome of Tako-tsubo cardiomyopathy.

Abstract

BACKGROUND:

Current data suggest an excellent outcome for patients with Tako-tsubo cardiomyopathy (TC). The objectives of this study were to evaluate the long-term outcome and the prognostic implication of thrombolysis in myocardial infarction myocardial perfusion grade (TMPG) in patients with TC.

METHODS:

Retrospective analysis of all patients diagnosed with TC at our hospital between 2003 and 2008.

RESULTS:

During the five-year period, we identified 27 patients with TC out of 1374 cases of emergent left heart catheterisation (2%). Mean follow-up was 27 ± 16 months. The majority were Caucasian (81%) female (96%), postmenopausal (96%), with a mean age of 68 ± 14 years. A precipitating stressor event was found in 74% of the patients, 30% being gastrointestinal triggers. Fourteen patients (52%) reached a combined end point of all cause death, cardiogenic shock, sudden cardiac death and rehospitalisation for cardiac reasons. TMPG was abnormal in 37% cases with no correlation with the outcome.

CONCLUSIONS:

The long-term outcome of patients with TC is worse than previously reported. TMPG does not correlate with the outcome in TC.

• Authors: Costin N Ionescu, Cesar A Aguilar-Lopez, Antoine E Sakr, Andre E Ghantous, Thomas J Donohue
• Journal: Heart, lung & circulation (Heart Lung Circ) Vol. 19 Issue 10 Pg. 601-5 (Oct 2010) ISSN: 1444-2892 [Electronic] Australia
• PMID: 20655278 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand. Published by Elsevier B.V. All rights reserved.

Chemical References

• Antihypertensive Agents
• Biomarkers
• Platelet Aggregation Inhibitors

Topics

• Adult
• Aged
• Aged, 80 and over
• Antihypertensive Agents (therapeutic use)
• Biomarkers
• Cardiac Catheterization
• Chest Pain
• Female
• Health Status Indicators
• Humans
• Male
• Middle Aged
• Platelet Aggregation Inhibitors (therapeutic use)
• Prognosis
• Retrospective Studies
• Statistics as Topic
• Takotsubo Cardiomyopathy (drug therapy, epidemiology, therapy)
• Time Factors
• Treatment Outcome