Effect of oral contraceptive containing ethinyl estradiol combined with drospirenone vs. desogestrel on clinical and biochemical parameters in patients with polycystic ovary syndrome.

Abstract

BACKGROUND:

A prospective randomized trial was conducted to compare efficacy of a drospirenone-containing combined oral contraceptives (COC) with desogestrel-containing COC in women with polycystic ovary-syndrome (PCOS) not desirous of child-bearing.

STUDY DESIGN:

Sixty women were randomized into study group [ethinylestradiol (EE) 30 mcg+drospirenone 3 mg] and control group (EE 30 mcg+desogestrel 150 mcg), treated for 6 months and followed up at 1 month, 3 months, 6 months, during treatment and 3 and 6 months post-treatment. Acne and hirsutism scoring, bodyweight, body mass index (BMI), blood pressure (BP), ultrasound parameters, lipid profile, glycemic profile and hormonal profile were compared.

RESULTS:

Cycles were regular in both groups during treatment. Effect of regular cycles persisted in 44.83% (13/30) vs. 17.24% (5/30) in study vs. control group at 6 months post-treatment with 33.3% decreased hirsutism score in the study group (versus no change in control group) even at 6 months after stopping treatment. With treatment, BMI fell by 0.52 kg/m(2) in the study group; systolic and diastolic BP fell in the study group while it rose in the control group. Low-density lipoprotein significantly decreased and high-density lipoprotein was elevated in the study group (p<.05). The study group showed a significant fall in fasting/postprandial blood sugar and insulin and total testosterone against a rise in the control group.

CONCLUSION:

In women with PCOS, a drospirenone containing COC has better outcome in terms of persistent regular cycles, antiandrogenic effect, fall in BMI and BP, better lipid profile, favorable glycemic and hormonal profile than desogestrel-containing COC.

• Authors: Alka Kriplani, Anurekha Janaki Periyasamy, Nutan Agarwal, Vidushi Kulshrestha, Anand Kumar, Ariachery Chinnama Ammini
• Journal: Contraception (Contraception) Vol. 82 Issue 2 Pg. 139-46 (Aug 2010) ISSN: 1879-0518 [Electronic] United States
• PMID: 20654754 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: Copyright 2010 Elsevier Inc. All rights reserved.

Chemical References

• Androstenes
• Blood Glucose
• Contraceptives, Oral, Combined
• Drug Combinations
• Insulin
• Lipoproteins, HDL
• Lipoproteins, LDL
• Triglycerides
• drospirenone and ethinyl estradiol combination
• Testosterone
• Ethinyl Estradiol
• Desogestrel

Topics

• Acne Vulgaris (metabolism)
• Adolescent
• Adult
• Androstenes (pharmacology, therapeutic use)
• Anthropometry
• Blood Glucose (analysis)
• Blood Pressure (physiology)
• Contraceptives, Oral, Combined (pharmacology, therapeutic use)
• Desogestrel (pharmacology, therapeutic use)
• Drug Combinations
• Ethinyl Estradiol (pharmacology, therapeutic use)
• Female
• Hirsutism (metabolism)
• Humans
• Insulin
• Lipoproteins, HDL (blood)
• Lipoproteins, LDL (blood)
• Polycystic Ovary Syndrome (drug therapy, metabolism)
• Prospective Studies
• Statistics, Nonparametric
• Testosterone
• Triglycerides (blood)
• Young Adult