[Association between beta3-adrenergic receptor and oxidative stress in chronic heart failure rats].

Abstract

OBJECTIVE:

To investigate the association between beta(3)-adrenergic receptor (beta(3)-AR) and oxidative stress in isoproterenol (ISO)-induced chronic heart failure (HF) rats.

METHODS:

Seven weight-matched normal adult rats (control), 18 ISO induced heart failure rats and 21 ISO induced heart failure rats treated with specific beta(3)-AR inhibitor, SR59230A for 6 weeks were included in this study. Echocardiography was performed at the end of the study and the myocardial levels of total superoxide dismutase (T-SOD) and lipid peroxidation (LPO) were measured by colorimetry, myocardial expression of beta(3)-AR was detected by reverse transcription-polymerase chain reaction (RT-PCR).

RESULT:

Compared with control group, the cardiac function was significantly reduced and myocardial beta(3)-AR mRNA expression was significantly increased, LPO level was also significantly enhanced while T-SOD level was significantly reduced in ISO group and these changes could be significantly attenuated by treatment with SR59230A.

CONCLUSION:

Our results showed that myocardial upregulation of beta(3)-AR is associated with increased oxidative stress in this model and beta(3)-AR inhibitor may be a new therapeutic agent for heart failure treatment.

• Authors: Yi-hui Kong, Ying Zhang, Na Li, Li Zhang, Yan-hui Gao, Hong-jie Xue, Yue Li, Wei-min Li
• Journal: Zhonghua xin xue guan bing za zhi (Zhonghua Xin Xue Guan Bing Za Zhi) Vol. 38 Issue 5 Pg. 435-9 (May 2010) ISSN: 0253-3758 [Print] China
• PMID: 20654104 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate
• Propanolamines
• Receptors, Adrenergic, beta-3
• Superoxide Dismutase

Topics

• Animals
• Gene Expression Regulation
• Heart Failure (metabolism, physiopathology)
• Lipid Peroxidation
• Male
• Myocardium (metabolism)
• Oxidative Stress
• Propanolamines (pharmacology)
• Rats
• Rats, Wistar
• Receptors, Adrenergic, beta-3 (metabolism)
• Superoxide Dismutase (metabolism)
• Up-Regulation